Lung cancer was considered to be rare in the beginning of the 20th century but has now reached almost epidemic proportions. It was the most commonly diagnosed cancer worldwide as well as the leading cause of cancer death in males in 2008. Among females, it was the fourth most commonly diagnosed cancer and the second leading cause of cancer death. Lung cancer accounts for 13% (1.6 million) of the total cases and 18% (1.4 million) of the deaths in 2008 and it will rise to three millions per year by the year 2010. Global incidence of lung cancer is increasing at 0.5% per year. According to the American Cancer Society, the chance that a man will develop lung cancer in his lifetime is about 1 in 13, for a woman, it is 1 in 16 (including smokers and non-smokers). According to the World Health Organization, three people die every minute worldwide from lung cancer which could be called 'one of the epidemics' of the 20th century.